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Gene/ORF Y48G1A.5 (imb-5) Ace View of Y48G1A.5
Y48G1A.5 Details Help
Description  imb-5 encodes an importin-beta-like protein orthologous to mammalian CAS proteins (cellular apoptosis susceptibility) and Saccharomyces cerevisiae CSE1 (chromosome segregation 1); IMB-5 is predicted to function in nuclear transport of proteins required for mitotic progression or apoptosis as well as in re-export of importin-alpha, a nuclear import protein; in C. elegans, IMB-5 is essential for embryogenesis and required for normal pronuclear envelope dynamics, and may also play a role in vulval morphogenesis.
Homology Group (KOG)  Nuclear export receptor CSE1/CAS (importin beta superfamily)
GO Terms  binding (GO:0005488) ; importin-alpha export receptor activity (GO:0008262) ; apoptosis (GO:0006915) ; cell proliferation (GO:0008283) ; nucleus (GO:0005634) ; cytoplasm (GO:0005737) ; protein transporter activity (GO:0008565) ; protein-nucleus import, docking (GO:0000059) ; nuclear pore (GO:0005643)
Location   I:318152..323753
RNAi Phenotypes
Early_embryo Pronuclear/Nuclear Appearance abnormal ; Pna ; Pna
Larva Lva ; Gro
Adult Sck ; Sck ; Pvl ; Unc ; Unc ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:Y48G1A_54.c:Screen_B Emb
Simmer:Y48G1A_54.b:Screen_A Emb ; Sck ; Ste ; Unc
JA:Y48G1A_54.b Emb ; Pna
JA:Y48G1A_54.c Emb ; Pna ; Pvl
Simmer:Y48G1A_54.b:Screen_B Emb
Cenix:152-a8 Emb ; Pronuclear/Nuclear Appearance abnormal
Simmer:Y48G1A_54.c:Screen_A Emb ; Gro ; Unc
Gene Plot of Y48G1A.5 Browse using GBrowse
Gene Map