Ace View of Y49E10.1 | |||||||||
Y49E10.1 Details | |||||||||
Description | rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. | ||||||||
Homology Group (KOG) | 26S proteasome regulatory complex, ATPase RPT6 |
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GO Terms | hydrolase activity (GO:0016787) ; protein catabolism (GO:0030163) ; nucleus (GO:0005634) ; cytoplasm (GO:0005737) ; nucleotide binding (GO:0000166) ; nucleoside triphosphatase activity (GO:0017111) ; ATP binding (GO:0005524) | ||||||||
Location | III:12369931..12372892 | ||||||||
RNAi Phenotypes |
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External Links | |||||||||
Associated RNAi Experiments | |||||||||
Cenix:331-g6 | |||||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||||
Adult Phenotypes | Sister Chromatid Separation abnormal (Cross-eyed) |
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RNAi Reagent Name & Type | Cenix:331-g6 (PCR reagent) | ||||||||
Delivery Method | Injection | ||||||||
Remark | early embryonic: Sister Chromatid Separation (Cross-eyed) | ||||||||
Laboratory | TH | ||||||||
Date | 2005-3-24 | ||||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||||
Simmer:Y49E10.1 | |||||||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||||||
Larval Phenotypes | Lva |
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Adult Phenotypes | Unc |
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RNAi Reagent Name & Type | sjj_Y49E10.1 (PCR reagent) | ||||||||
Laboratory | NL | ||||||||
Date | 2003-10-01 | ||||||||
Strain | NL4256 rrf-3(pk1426) | ||||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||||
TH:331G6 | |||||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||||
RNAi Reagent Name & Type | TH:331G6 (PCR reagent) | ||||||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (Y49E10.1-RNA2; less penetrant DIC phenotype); not confirmed with third dsRNA (Y49E10.1-RNA3). | ||||||||
Laboratory | TH | ||||||||
Date | 2000-11-16 | ||||||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||||||
TH:341D12 | |||||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||||
RNAi Reagent Name & Type | TH:341D12 (PCR reagent) | ||||||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (Y49E10.1-RNA2; less penetrant DIC phenotype); not confirmed with third dsRNA (Y49E10.1-RNA3). | ||||||||
Laboratory | TH | ||||||||
Date | 2000-11-16 | ||||||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||||||
Cenix:341-d12 | |||||||||
Adult Phenotypes | Larval Lethal-Early (L1/L2) |
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RNAi Reagent Name & Type | Cenix:341-d12 (PCR reagent) | ||||||||
Delivery Method | Injection | ||||||||
Remark | post-embryonic: Larval Lethal-Early (L1/L2) | ||||||||
Laboratory | TH | ||||||||
Date | 2005-3-24 | ||||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||||
Gene Plot of Y49E10.1 | |||||||||