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Gene/ORF Y49E10.1 (rpt-6) Ace View of Y49E10.1
Y49E10.1 Details Help
Description  rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
Homology Group (KOG)  26S proteasome regulatory complex, ATPase RPT6
GO Terms  hydrolase activity (GO:0016787) ; protein catabolism (GO:0030163) ; nucleus (GO:0005634) ; cytoplasm (GO:0005737) ; nucleotide binding (GO:0000166) ; nucleoside triphosphatase activity (GO:0017111) ; ATP binding (GO:0005524)
Location   III:12369931..12372892
RNAi Phenotypes
Early_embryo Sister Chromatid Separation abnormal (Cross-eyed)
Postembryonic Larval Arrest-Early (L1/L2) ; Larval Lethal-Early (L1/L2)
Larva Lva ; Gro ; Gro
Adult Clr ; Lon ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:331-g6
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Sister Chromatid Separation abnormal (Cross-eyed)
RNAi Reagent Name & Type Cenix:331-g6 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Sister Chromatid Separation (Cross-eyed)
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Simmer:Y49E10.1
Embryonic Phenotypes  Emb Penetrance 100 %
Larval Phenotypes  Lva
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_Y49E10.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:331G6
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:331G6 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (Y49E10.1-RNA2; less penetrant DIC phenotype); not confirmed with third dsRNA (Y49E10.1-RNA3).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:341D12
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:341D12 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (Y49E10.1-RNA2; less penetrant DIC phenotype); not confirmed with third dsRNA (Y49E10.1-RNA3).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Cenix:341-d12
Adult Phenotypes  Larval Lethal-Early (L1/L2)
RNAi Reagent Name & Type Cenix:341-d12 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Larval Lethal-Early (L1/L2)
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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