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Gene/ORF Y49E10.14 (pie-1) Ace View of Y49E10.14
Y49E10.14 Details Help
Description  pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
Homology Group (KOG)  CCCH-type Zn-finger protein
GO Terms  cell fate determination (GO:0001709) ; formation of primary germ layer (GO:0001704) ; negative regulation of transcription (GO:0016481) ; embryonic pattern specification (GO:0009880) ; nucleus (GO:0005634) ; centrosome (GO:0005813) ; general transcriptional repressor activity (GO:0016565) ; nucleic acid binding (GO:0003676)
Location   III:12426368..12429450
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:340-e4
RNAi Reagent Name & Type Cenix:340-e4 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Ambiguous result
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:Y49E10.14
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_Y49E10.14 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:Y49E10.14
Embryonic Phenotypes  Emb Penetrance 100 %
RNAi Reagent Name & Type sjj_Y49E10.14 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:331B9
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:331B9 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:340E4
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:340E4 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
Cenix:331-b9
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:331-b9 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of Y49E10.14 Browse using GBrowse
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