Ace View of Y54E5B.3 | |||||||
Y54E5B.3 Details | |||||||
Description | let-49 encodes a putative mediator complex subunit zygotically required for postembryonic development and viability past larval stages, while being maternally required for germline and embryonic development; LET-49 is an ortholog of human CRSP9 (OMIM:605045) and of S. cerevisiae Med7p; Med7p is a component of a mediator complex that serves as a transcriptional coactivator, while CRSP9 mediates transcriptional activation by Sp1. | ||||||
Homology Group (KOG) | Transcriptional coactivator |
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GO Terms | transcription co-activator activity (GO:0003713) ; positive regulation of transcription (GO:0045941) ; nucleus (GO:0005634) | ||||||
Location | I:14820008..14821978 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
JA:Y54E5B.3 | |||||||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % Led (Differentiated, not enclosed) | ||||||
Adult Phenotypes | Rup |
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RNAi Reagent Name & Type | sjj_Y54E5B.3 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2000-11-16 | ||||||
Reference | Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...." | Movies/Stacks/Images | |||||
Simmer:Y54E5B.3:Screen_A | |||||||
Larval Phenotypes | Gro |
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Adult Phenotypes | Dpy Pvl Stp |
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RNAi Reagent Name & Type | sjj_Y54E5B.3 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Simmer:Y54E5B.3:Screen_B | |||||||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % | ||||||
Larval Phenotypes | Gro |
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Adult Phenotypes | Dpy Pvl Stp Unc |
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RNAi Reagent Name & Type | sjj_Y54E5B.3 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
Cenix:34-c8 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
Adult Phenotypes | WT_postembryonic_morphology |
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RNAi Reagent Name & Type | Cenix:34-c8 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: Clear cut result. | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
Gene Plot of Y54E5B.3 | |||||||