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Gene/ORF Y54E5B.3 (let-49) Ace View of Y54E5B.3
Y54E5B.3 Details Help
Description  let-49 encodes a putative mediator complex subunit zygotically required for postembryonic development and viability past larval stages, while being maternally required for germline and embryonic development; LET-49 is an ortholog of human CRSP9 (OMIM:605045) and of S. cerevisiae Med7p; Med7p is a component of a mediator complex that serves as a transcriptional coactivator, while CRSP9 mediates transcriptional activation by Sp1.
Homology Group (KOG)  Transcriptional coactivator
GO Terms  transcription co-activator activity (GO:0003713) ; positive regulation of transcription (GO:0045941) ; nucleus (GO:0005634)
Location   I:14820008..14821978
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Gro ; Gro
Adult Dpy ; Dpy ; Pvl ; Pvl ; Unc ; Rup ; Stp ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:Y54E5B.3
Embryonic Phenotypes  Emb Penetrance 50 - 80 % Led (Differentiated, not enclosed)
Adult Phenotypes  Rup
RNAi Reagent Name & Type sjj_Y54E5B.3 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
Simmer:Y54E5B.3:Screen_A
Larval Phenotypes  Gro
Adult Phenotypes  Dpy
Pvl
Stp
RNAi Reagent Name & Type sjj_Y54E5B.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:Y54E5B.3:Screen_B
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Larval Phenotypes  Gro
Adult Phenotypes  Dpy
Pvl
Stp
Unc
RNAi Reagent Name & Type sjj_Y54E5B.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:34-c8
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:34-c8 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Clear cut result.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of Y54E5B.3 Browse using GBrowse
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