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Gene/ORF Y73C8B.4 (lag-2) Ace View of Y73C8B.4
Y73C8B.4 Details Help
Description  lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex.
Homology Group (KOG)  Proteins containing Ca2+-binding EGF-like domains
GO Terms  cell fate specification (GO:0001708) ; cell communication (GO:0007154) ; membrane (GO:0016020)
Location   V:3187777..3190068
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:154-f1 WT
JA:Y73C8B.d WT
JA:Y73C8B.b WT
Gene Plot of Y73C8B.4 Browse using GBrowse
Gene Map