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Gene/ORF Y75B8A.26 (mrp-8) Ace View of Y75B8A.26
Y75B8A.26 Details Help
Description  mrp-8 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCC subfamily of ABC transporters that includes the multidrug resistance-associated proteins and the cystic fibrosis transmembrane conductance regulator; by homology, MRP-8 is predicted to function as an ATP-dependent organic anion transporter that transports molecules across the plasma membrane into the extracellular space; at present, the precise role of MRP-8 in C. elegans development and/or behavior is not yet known.
Homology Group (KOG)  Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily
GO Terms  nucleotide binding (GO:0000166) ; nucleoside triphosphatase activity (GO:0017111) ; ATP binding (GO:0005524) ; ATPase activity, coupled to transmembrane movement of substances (GO:0042626) ; transport (GO:0006810) ; integral to membrane (GO:0016021) ; ATPase activity (GO:0016887)
Location   III:12282683..12295285
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:333-a9
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:333-a9 (PCR reagent)
Delivery Method  Injection
Remark  wild type
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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