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Gene/ORF Y92C3B.2 (uaf-1) Ace View of Y92C3B.2
Y92C3B.2 Details Help
Description  uaf-1 encodes the large subunit of U2AF, the U2 small nuclear ribonucleoparticle (snRNP) auxiliary factor and is a homolog of mammalian and fly U2AF65; UAF-1 has been shown to bind RNA and this binding is enhanced by UAF-2; the abundance of one alternative transcript appears to be increased during starvation and this transcript is retained in the nucleus; uaf-1 affects embryonic viability, based on RNAi analysis.
Homology Group (KOG)  Splicing factor U2AF, large subunit (RRM superfamily)
GO Terms  nuclear mRNA splicing via U2-type spliceosome (GO:0006374) ; embryonic development (GO:0009790) ; spliceosome complex (GO:0005681) ; RNA binding (GO:0003723) ; nucleotide binding (GO:0000166) ; nucleic acid binding (GO:0003676) ; mRNA processing (GO:0006397) ; nucleus (GO:0005634)
Location   III:1062381..1076943
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Larva Let ; Lvl
Adult Pvl ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:191-g9 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Clear-cut result.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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