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Gene/ORF ZK1151.1 (vab-10) Ace View of ZK1151.1
ZK1151.1 Details Help
Description  vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP.
Homology Group (KOG)  Dystonin, GAS (Growth-arrest-specific protein), and related proteins
GO Terms  actin binding (GO:0003779) ; calcium ion binding (GO:0005509) ; cell cycle arrest (GO:0007050)
Location   I:11747016..11792506
RNAi Phenotypes
Postembryonic Prz ; Prz ; WT_postembryonic_morphology ; WT_postembryonic_morphology
Larva Let ; Lva ; Lva ; Lvl ; Lvl ; Lvl ; Gro
Adult Bmd ; Bmd ; Bmd ; Pvl ; Pvl ; Unc ; Unc ; Unc ; Ste ; Rup ; Rup ; Rup ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:ZK1151.1 WT
Cenix:155-d9 WT
Experiments with Non-Wild Phenotypes
Simmer:ZK1151.2:Screen_A Bmd ; Gro ; Lvl ; Rup ; Unc
JA:ZK1151.2 Bmd ; Stp ; Unc
Cenix:20-f11
Simmer:ZK1151.1:Screen_B Emb
Cenix:29-e9 Emb ; WT_postembryonic_morphology
Simmer:ZK1151.1:Repeat_b Lva ; Lvl ; Prz ; Pvl ; Rup
Simmer:ZK1151.1:Screen_A Prz ; Pvl ; Rup ; Ste
Cenix:63-f12 Emb ; WT_postembryonic_morphology
Simmer:ZK1151.2:Screen_B Bmd ; Lva ; Lvl ; Unc
Gene Plot of ZK1151.1 Browse using GBrowse
Gene Map