Gene/ORF
ZK1151.1 (vab-10)
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Ace View of ZK1151.1
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ZK1151.1 Details |
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Description |
vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP. |
Homology Group (KOG) |
Dystonin, GAS (Growth-arrest-specific protein), and related proteins
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GO Terms |
actin binding
(GO:0003779) ; calcium ion binding
(GO:0005509) ; cell cycle arrest
(GO:0007050) |
Location |
I:11747016..11792506 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Wild Type RNAi Experiments |
JA:ZK1151.1 |
WT |
Cenix:155-d9 |
WT |
Experiments with Non-Wild Phenotypes |
Simmer:ZK1151.2:Screen_A |
Bmd ; Gro ; Lvl ; Rup ; Unc |
JA:ZK1151.2 |
Bmd ; Stp ; Unc |
Cenix:20-f11 |
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Simmer:ZK1151.1:Screen_B |
Emb |
Cenix:29-e9 |
Emb ; WT_postembryonic_morphology |
Simmer:ZK1151.1:Repeat_b |
Lva ; Lvl ; Prz ; Pvl ; Rup |
Simmer:ZK1151.1:Screen_A |
Prz ; Pvl ; Rup ; Ste |
Cenix:63-f12 |
Emb ; WT_postembryonic_morphology |
Simmer:ZK1151.2:Screen_B |
Bmd ; Lva ; Lvl ; Unc |
Gene Plot of ZK1151.1 |
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