Ace View of ZK381.1 | |||
ZK381.1 Details | |||
Description | him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes. | ||
Homology Group (KOG) | HORMA domain |
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GO Terms | meiosis I, chromosome segregation (GO:0045143) ; sister chromatid cohesion (GO:0007062) ; synaptonemal complex formation (GO:0007130) ; condensed nuclear chromosome (GO:0000794) ; DNA binding (GO:0003677) | ||
Location | IV:6977103..6979142 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:15-e9 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:15-e9 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | 3/3 tests are wildtype. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
JA:ZK381.1 | |||
Embryonic Phenotypes | Emb Penetrance 10 % | ||
Adult Phenotypes | Him |
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RNAi Reagent Name & Type | sjj_ZK381.1 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
PF:GL1_4C3 | |||
Embryonic Phenotypes | Emb Penetrance 30 % | ||
Adult Phenotypes | Him
>0.4% male progeny observed. |
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RNAi Reagent Name & Type | sjj_ZK381.1 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | PCR product contains flanking T7 promoter sequences | ||
Laboratory | KK | ||
Date | 2002-11-19 | ||
Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | ||
Gene Plot of ZK381.1 | |||