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Gene/ORF ZK381.1 (him-3) Ace View of ZK381.1
ZK381.1 Details Help
Description  him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes.
Homology Group (KOG)  HORMA domain
GO Terms  meiosis I, chromosome segregation (GO:0045143) ; sister chromatid cohesion (GO:0007062) ; synaptonemal complex formation (GO:0007130) ; condensed nuclear chromosome (GO:0000794) ; DNA binding (GO:0003677)
Location   IV:6977103..6979142
RNAi Phenotypes
Adult Him ; Him
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:15-e9
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:15-e9 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:ZK381.1
Embryonic Phenotypes  Emb Penetrance 10 %
Adult Phenotypes  Him
RNAi Reagent Name & Type sjj_ZK381.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
PF:GL1_4C3
Embryonic Phenotypes  Emb Penetrance 30 %
Adult Phenotypes  Him >0.4% male progeny observed.
RNAi Reagent Name & Type sjj_ZK381.1 (PCR reagent)
Delivery Method  Injection
Remark  PCR product contains flanking T7 promoter sequences
Laboratory  KK
Date  2002-11-19
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Gene Plot of ZK381.1 Browse using GBrowse
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