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Gene/ORF ZK617.1 (unc-22) Ace View of ZK617.1
ZK617.1 Details Help
Description  unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation.
Homology Group (KOG)  Projectin/twitchin and related proteins
GO Terms  protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein serine/threonine kinase activity (GO:0004674) ; tRNA ligase activity (GO:0004812) ; amino acid activation (GO:0006418) ; protein-tyrosine kinase activity (GO:0004713)
Location   IV:11972278..12011377
RNAi Phenotypes
Postembryonic Prz
Adult Unc ; Unc ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:155-g4
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:155-g4 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:ZK617.1
Adult Phenotypes  Unc
RNAi Reagent Name & Type sjj_ZK617.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:ZK617.1
Adult Phenotypes  Unc
Adult Phenotypes  Prz
RNAi Reagent Name & Type sjj_ZK617.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of ZK617.1 Browse using GBrowse
Gene Map