Ace View of ZK617.1 | |||||
ZK617.1 Details | |||||
Description | unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation. | ||||
Homology Group (KOG) | Projectin/twitchin and related proteins |
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GO Terms | protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein serine/threonine kinase activity (GO:0004674) ; tRNA ligase activity (GO:0004812) ; amino acid activation (GO:0006418) ; protein-tyrosine kinase activity (GO:0004713) | ||||
Location | IV:11972278..12011377 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:155-g4 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:155-g4 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | Wildtype results in all three tests. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:ZK617.1 | |||||
Adult Phenotypes | Unc |
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RNAi Reagent Name & Type | sjj_ZK617.1 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:ZK617.1 | |||||
Adult Phenotypes | Unc |
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Adult Phenotypes | Prz |
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RNAi Reagent Name & Type | sjj_ZK617.1 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of ZK617.1 | |||||