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Gene/ORF ZK617.1 (unc-22) Ace View of ZK617.1
ZK617.1 Details Help
Description  unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation.
Homology Group (KOG)  Projectin/twitchin and related proteins
GO Terms  protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) ; protein serine/threonine kinase activity (GO:0004674) ; tRNA ligase activity (GO:0004812) ; amino acid activation (GO:0006418) ; protein-tyrosine kinase activity (GO:0004713)
Location   IV:11972278..12011377
RNAi Phenotypes
Postembryonic Prz
Adult Unc ; Unc ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:155-g4 WT
Experiments with Non-Wild Phenotypes
JA:ZK617.1 Unc
Simmer:ZK617.1 Prz ; Unc
Gene Plot of ZK617.1 Browse using GBrowse
Gene Map