Description |
lin-15A encodes a novel, hydrophilic protein; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LET-23 receptor tyrosine and redundantly with class B synMuv genes, such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1; although the lin-15A expression pattern is not yet known, genetic mosaic analysis suggests that, in regulating vulval induction, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue. |