Gene/ORF
ZK770.3 (inx-12)
|
Ace View of ZK770.3
|
ZK770.3 Details |
|
Description |
inx-12 (innexin=invertebrate connexin analogue) encodes a protein of the innexin family; innexins are gap junction proteins similar in function, though dissimilar in sequence to the vertebrate connexins; innexins are the only known gap junction proteins in invertebrates; inx-12 and inx-13 appear to be a tandom duplication; RNA interference of inx-12 results in an arrest at the L1 larval stage with fluid filled dead rods; this phenotype and sequence homology to Drosophila innexins suggest that INX-12 may be required to form gap junctions between the excretory canal and hypodermis, thus playing an essential role in osmoregulation; an INX-12::GFP fusion protein is expressed in the excretory canal. |
GO Terms |
gap junction assembly
(GO:0016264) ; osmoregulation
(GO:0018987) ; gap junction
(GO:0005921) ; innexin channel activity
(GO:0015286) |
Location |
I:3755106..3759448 |
RNAi Phenotypes |
|
External Links |
|
Associated RNAi Experiments |
View Details
|
Wild Type RNAi Experiments |
JA:ZK770.3 |
WT |
Cenix:233-h12 |
WT |
Simmer:ZK770.3:Repeat_a |
WT |
Simmer:ZK770.3:Repeat_b |
WT |
Experiments with Non-Wild Phenotypes |
Simmer:ZK770.3:Screen_B |
Gro ; Pvl ; Rup ; Stp ; Unc |
Gene Plot of ZK770.3 |
Browse using GBrowse
|
|