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Gene/ORF ZK770.3 (inx-12) Ace View of ZK770.3
ZK770.3 Details Help
Description  inx-12 (innexin=invertebrate connexin analogue) encodes a protein of the innexin family; innexins are gap junction proteins similar in function, though dissimilar in sequence to the vertebrate connexins; innexins are the only known gap junction proteins in invertebrates; inx-12 and inx-13 appear to be a tandom duplication; RNA interference of inx-12 results in an arrest at the L1 larval stage with fluid filled dead rods; this phenotype and sequence homology to Drosophila innexins suggest that INX-12 may be required to form gap junctions between the excretory canal and hypodermis, thus playing an essential role in osmoregulation; an INX-12::GFP fusion protein is expressed in the excretory canal.
GO Terms  gap junction assembly (GO:0016264) ; osmoregulation (GO:0018987) ; gap junction (GO:0005921) ; innexin channel activity (GO:0015286)
Location   I:3755106..3759448
RNAi Phenotypes
Larva Gro
Adult Pvl ; Unc ; Rup ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:ZK770.3 WT
Cenix:233-h12 WT
Simmer:ZK770.3:Repeat_a WT
Simmer:ZK770.3:Repeat_b WT
Experiments with Non-Wild Phenotypes
Simmer:ZK770.3:Screen_B Gro ; Pvl ; Rup ; Stp ; Unc
Gene Plot of ZK770.3 Browse using GBrowse
Gene Map