Ace View of ZK858.4 | |||||||
ZK858.4 Details | |||||||
Description | mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. | ||||||
Homology Group (KOG) | Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains |
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GO Terms | protein binding (GO:0005515) | ||||||
Location | I:9132129..9136127 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Experiments with Non-Wild Phenotypes | |||||||
Simmer:ZK858.4:Screen_B | Bmd ; Emb | ||||||
JA:ZK858.4 | Abs ; Emb | ||||||
Cenix:81-d9 | Emb ; Spindle Elongation/Integrity abnormal | ||||||
Simmer:ZK858.4:Screen_A | Dpy ; Emb | ||||||
Gene Plot of ZK858.4 | |||||||