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Gene/ORF ZK858.4 (mel-26) Ace View of ZK858.4
ZK858.4 Details Help
Description  mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.
Homology Group (KOG)  Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains
GO Terms  protein binding (GO:0005515)
Location   I:9132129..9136127
RNAi Phenotypes
Early_embryo Spindle Elongation/Integrity abnormal ; Abs
Larva Lva
Adult Bmd ; Dpy
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:ZK858.4:Screen_B Bmd ; Emb
JA:ZK858.4 Abs ; Emb
Cenix:81-d9 Emb ; Spindle Elongation/Integrity abnormal
Simmer:ZK858.4:Screen_A Dpy ; Emb
Gene Plot of ZK858.4 Browse using GBrowse
Gene Map