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Gene/ORF ZK973.6 (anc-1) Ace View of ZK973.6
ZK973.6 Details Help
Description  anc-1 encodes a 8546-residue protein, orthologous of Drosophila Msp-300 and mammalian Syne proteins, which may extend more than 0.5 micrometers in vivo; ANC-1 has coiled regions, a nuclear envelope localization domain (the KASH domain) and an actin-binding domain; ANC-1 affects the positioning of nuclei and mitochondria within the cytoskeleton; ANC-1 is expressed in the cytoplasm, but localized to the nuclear periphery in an UNC-84-dependent manner.
Homology Group (KOG)  Dystonin, GAS (Growth-arrest-specific protein), and related proteins
GO Terms  cytoskeleton organization and biogenesis (GO:0007010) ; localization (GO:0051179) ; cytoplasm (GO:0005737) ; actin binding (GO:0003779) ; lipid binding (GO:0008289) ; lipid transport (GO:0006869) ; lipoprotein metabolism (GO:0042157) ; extracellular (GO:0005576)
Location   I:4320696..4359481
RNAi Phenotypes
Larva Mlt ; Mlt ; Mlt ; Mlt ; Lvl ; Lvl ; Lvl ; Lvl ; Gro ; Gro ; Gro ; Gro ; Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:166-c12
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:166-c12 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:244-d10
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:244-d10 (PCR reagent)
Delivery Method  Injection
Remark  Wildtype results in all three tests.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:77-f2
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:77-f2 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests with wildtype results.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:T03A1.3
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T03A1.3 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
JA:T03A1.4
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_T03A1.4 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
JA:ZK973.e
Larval Phenotypes  Lvl
Mlt
RNAi Reagent Name & Type sjj_ZK973.e (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:ZK973.f
Larval Phenotypes  Lvl
Mlt
RNAi Reagent Name & Type sjj_ZK973.f (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:ZK973.g
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.g (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:ZK973.h
Larval Phenotypes  Lvl
Mlt
RNAi Reagent Name & Type sjj_ZK973.h (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:ZK973.i
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.i (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:ZK973.e:Screen_A
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.e (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.e:Screen_B
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_ZK973.e (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.f:Screen_A
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.f (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.f:Screen_B
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_ZK973.f (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.g:Repeat_b
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.g (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.g:Screen_A
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.g (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.g:Screen_B
Larval Phenotypes  Gro could not be confirmed by re-testing
RNAi Reagent Name & Type sjj_ZK973.g (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.h:Screen_A
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.h (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.h:Screen_B
Larval Phenotypes  Gro
RNAi Reagent Name & Type sjj_ZK973.h (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.i:Repeat_b
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.i (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.i:Screen_A
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_ZK973.i (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Simmer:ZK973.i:Screen_B
Larval Phenotypes  Gro could not be confirmed by re-testing
RNAi Reagent Name & Type sjj_ZK973.i (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
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Gene Map