Link to B0207.4RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
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RNAi Experiment: [cgc4544]:air-2 Ace View of [cgc4544]:air-2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0207.4 (air-2)
Description of "B0207.4"  air-2 encodes an aurora/Ip11-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies.
KOG Annotation  Serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 912
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0207.4" Links  Wormbase NCBI
[cgc4544]:air-2 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
[cgc4544]:air-2 Experiment Details Ace View
Laboratory  EU
RNAi Reagent & Type  yk483g8 (cDNA_reagent)
Remark  DIC phenotype -- Reduced cleavage furrow ingression in second embryonic division; a phenotype not observed in either single (or36 mutation or air-2 RNAi) treatments, cf RNAi [cgc4544]:zen-4
Reference  Severson AF et al. (2000) Current Biology "The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle ...."
Delivery Method  Injection
Date  2000-9-11
Gene Plot of B0207.4 Browse using GBrowse
Gene Graph