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RNAi Experiment: [cgc4576]:gpb-1 Ace View of [cgc4576]:gpb-1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F13D12.7 (gpb-1)
Description of "F13D12.7"  gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
KOG Annotation  G-protein beta subunit
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1939
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F13D12.7" Links  Wormbase NCBI
[cgc4576]:gpb-1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
[cgc4576]:gpb-1 Experiment Details Ace View
Laboratory  JA
RNAi Reagent & Type  yk64c5 (cDNA_reagent)
Remark  template cDNA yk64c5
Reference  Gotta M et al. (2001) Nature Cell Biology "Distinct roles for G alpha and G beta gamma in regulating spindle position and ...."
Delivery Method  Injection
Date  2001-3-01
Gene Plot of F13D12.7 Browse using GBrowse
Gene Graph