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RNAi Experiment: [cgc4736]:hcp-3 Ace View of [cgc4736]:hcp-3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F58A4.3 (hcp-3)
Description of "F58A4.3"  The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
KOG Annotation  Histones H3 and H4
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 833
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F58A4.3" Links  Wormbase NCBI
[cgc4736]:hcp-3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
[cgc4736]:hcp-3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  yk325d10 (cDNA_reagent)
Remark  hcp-3 aka CeCENP-A
Reference  Oegema K et al. (2001) Journal of Cell Biology "Functional analysis of kinetochore assembly in Caenorhabditis ...."
Delivery Method  Injection
Date  2001-6-11
Gene Plot of F58A4.3 Browse using GBrowse
Gene Graph