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RNAi Experiment: [cgc4997]:sep-1:2 Ace View of [cgc4997]:sep-1:2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y47G6A.12 (sep-1)
Description of "Y47G6A.12"  The sep-1 gene encodes a homolog of separase, a protease that splits segregating chromosomes at their centromeres during anaphase by proteolyzing the Scc1 subunit of cohesin.
KOG Annotation  Regulator of spindle pole body duplication
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 3065
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y47G6A.12" Links  Wormbase NCBI
[cgc4997]:sep-1:2 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Mei alignment of bivalents on the first meiotic spindle occurred normally in sep-1(RNAi)embryos, but the chromosome segregation was delayed or never occured.
[cgc4997]:sep-1:2 Experiment Details Ace View
RNAi Reagent & Type  yk429h5 (cDNA_reagent)
Strain  N2
Remark  RNAi was performed in H2B::GFP background
Reference  Siomos MF et al. (2001) Current Biology "Separase is required for chromosome segregation during meiosis I in ...."
Delivery Method  Soaking
Date  2001-10-09
Gene Plot of Y47G6A.12 Browse using GBrowse
Gene Graph