| RNAi Experiment: [cgc5259]:ptp-3 |
Ace View of [cgc5259]:ptp-3
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| Genes Inhibited |
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| Gene Inhibited |
C09D8.1 (ptp-3) |
| Description of "C09D8.1" |
ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. |
| Evidence for Inhibition |
| Sliding Window |
Raw score: 1192
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "C09D8.1" Links |
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| [cgc5259]:ptp-3 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
| Phenotype |
Morphology defect
larval abnormalities averaged 1.1% (range 0 to 9.1%)
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| [cgc5259]:ptp-3 Experiment Details |
Ace View |
| Laboratory |
MT |
| RNAi Reagent & Type |
[cgc5259]:ptp-3 (cDNA_reagent) |
| Strain |
N2 |
| Reference |
Harrington RJ et al. (2002) Development "The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph ...." |
| Delivery Method |
Injection |
| Date |
2002-1-16 |
| Gene Plot of C09D8.1 |
Browse using GBrowse
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