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RNAi Experiment: [cgc5260]:cki-1:2 Ace View of [cgc5260]:cki-1:2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T05A6.1 (cki-1)
Description of "T05A6.1"  cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms.
KOG Annotation  Cyclin-dependent kinase inhibitor
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 762
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T05A6.1" Links  Wormbase NCBI
[cgc5260]:cki-1:2 Phenotypes Help with Phenotypes
Phenotype  Unclassified double mutant (cdc-25.1(rr31); cki-1(RNAi)) shows an increase in the number of intestinal nuclei at hatching (45+-7) compared with the single mutants (38+-3 for cdc-25.1(rr31) mutants, and 29+-3 for cki-1(RNAi) animals)
[cgc5260]:cki-1:2 Experiment Details Ace View
RNAi Reagent & Type  [cgc5260]:cki-1 (cDNA_reagent)
Strain  MR142
Reference  Kostic I et al. (2002) Development "Organ-specific cell division abnormalities caused by mutation in a general cell ...."
Delivery Method  Injection
Date  2002-2-08
Gene Plot of T05A6.1 Browse using GBrowse
Gene Graph