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RNAi Experiment: [cgc5260]:pop-1:2 Ace View of [cgc5260]:pop-1:2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W10C8.2 (pop-1)
Description of "W10C8.2"  pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
KOG Annotation  Transcription factor TCF-4
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1233
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W10C8.2" Links  Wormbase NCBI
[cgc5260]:pop-1:2 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
[cgc5260]:pop-1:2 Experiment Details Ace View
RNAi Reagent & Type  [cgc5260]:pop-1 (cDNA_reagent)
Strain  MR142
Reference  Kostic I et al. (2002) Development "Organ-specific cell division abnormalities caused by mutation in a general cell ...."
Delivery Method  Injection
Date  2002-2-08
Gene Plot of W10C8.2 Browse using GBrowse
Gene Graph