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RNAi Experiment: [cgc5277]:apr-1:3 Ace View of [cgc5277]:apr-1:3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04G2.8 (apr-1)
Description of "K04G2.8"  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
KOG Annotation  Beta-catenin-binding protein APC, contains ARM repeats
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 3741
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K04G2.8" Links  Wormbase NCBI
[cgc5277]:apr-1:3 Phenotypes Help with Phenotypes
Adult  Muv %Overinduced increased from 63% in control animals to 81% in RNAi-fed animals.
[cgc5277]:apr-1:3 Experiment Details Ace View
Laboratory  EW
RNAi Reagent & Type  [cgc5277]:apr-1 (cDNA_reagent)
Remark  RNAi was performed in hs::delNTbar-1 background. To avoid embryonic lethality, animals were fed dsRNA-expressing bacteria starting at the L1 stage and the vulval phenotype of these same animals was examined later in the L4 stage.
Reference  Gleason JE et al. (2002) Genes & Development "Activatin of Wnt signaling bypasses the requirement for RTK/Ras signaling ...."
Delivery Method  Bacterial_feeding
Date  2002-3-29
Gene Plot of K04G2.8 Browse using GBrowse
Gene Graph