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RNAi Experiment: [cgc5318]:let-502 Ace View of [cgc5318]:let-502
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C10H11.9 (let-502)
Description of "C10H11.9"  let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization.
KOG Annotation  Rho-associated, coiled-coil containing protein kinase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 4044
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C10H11.9" Links  Wormbase NCBI
[cgc5318]:let-502 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
[cgc5318]:let-502 Experiment Details Ace View
Laboratory  HR
RNAi Reagent & Type  [cgc5318]:let-502 (cDNA_reagent)
Remark  RNAi was performed in let-502(sb106) genetic background
Reference  Piekny AJ et al. (2002) Journal of Cell Science "Rho-binding kinase (LET-502) and myosin phosphate (MEL-11) regulate ...."
Delivery Method  Injection
Date  2002-3-26
Gene Plot of C10H11.9 Browse using GBrowse
Gene Graph