| RNAi Experiment: [cgc5322]:hcp-3 |
Ace View of [cgc5322]:hcp-3
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| Genes Inhibited |
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| Gene Inhibited |
F58A4.3 (hcp-3) |
| Description of "F58A4.3" |
The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. |
| KOG Annotation |
Histones H3 and H4
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| Evidence for Inhibition |
| Sliding Window |
Raw score: 783
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "F58A4.3" Links |
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| [cgc5322]:hcp-3 Phenotypes |
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| Phenotype |
Unclassified
in the absence of HCP-3, HCP-6 does not assemble onto mitotic chromosomes properly
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| [cgc5322]:hcp-3 Experiment Details |
Ace View |
| Laboratory |
AR |
| RNAi Reagent & Type |
[cgc5322]:hcp-3 (cDNA_reagent) |
| Strain |
WT |
| Reference |
Stear JH et al. (2002) Genes & Development "Characterization of HCP-6, a C. elegans protein required to prevent chromosome ...." |
| Delivery Method |
Injection |
| Date |
2002-4-29 |
| Gene Plot of F58A4.3 |
Browse using GBrowse
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