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RNAi Experiment: [cgc5344]:eor-1:1 Ace View of [cgc5344]:eor-1:1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R11E3.6 (eor-1)
Description of "R11E3.6"  eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes.
KOG Annotation  Zn-finger
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 1393
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R11E3.6" Links  Wormbase NCBI
[cgc5344]:eor-1:1 Phenotypes Help with Phenotypes
Larval  Let RNAi resulted in 24% lethality in lin-1(e1275) animals
[cgc5344]:eor-1:1 Experiment Details Ace View
Laboratory  UP
RNAi Reagent & Type  yk151c9 (cDNA_reagent)
Strain  CB1275
Reference  Howard RM et al. (2002) Genes & Developement "C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and ...."
Delivery Method  Injection
Date  2002-5-22
Gene Plot of R11E3.6 Browse using GBrowse
Gene Graph