RNAi Card Page

RNAi Experiment: [cgc5655]:daf-2:R05F9.8

Genes Inhibited

Gene Inhibited

Description of "R05F9.8"

msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-33 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

ePCR	Status: Unique_ePCR (II:4891673..4892704) Transcript overlap: 448 nt
Sliding Window	Raw score: 406 Relative score: 1 (This gene has the best score for this RNAi reagent) Specificity index: 0.119
Wormbase (BLAST)	RNAi primary

External "R05F9.8" Links

Gene Inhibited

R05F9.5 (gst-9)

Description of "R05F9.5"

gst-9 encodes a predicted glutathione S-transferase; by homology, GST-9 is predicted to play a role in the detoxification of environmental toxins and xenobiotics by transferring glutathione to reactive electrophilic compounds; however, as loss of gst-9 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GST-9 in C. elegans development and/or behavior is not yet known.

KOG Annotation

Glutathione S-transferase

Evidence for Inhibition

ePCR	Transcript overlap: 35 nt
Wormbase (BLAST)	RNAi primary

External "R05F9.5" Links

Gene Inhibited

Y59E9AR.7

Description of "Y59E9AR.7"

Associated GO Term : structural molecule activity

Evidence for Inhibition

Sliding Window	Raw score: 98 Specificity index: 0.029
Wormbase (BLAST)	RNAi secondary

External "Y59E9AR.7" Links

Gene Inhibited

R05F9.3 (msp-32)

Description of "R05F9.3"

msp-32 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-32 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the msp family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 146 Relative score: 0.36 (Best raw score= for Gene ) Specificity index: 0.043
Wormbase (BLAST)	RNAi primary

External "R05F9.3" Links

Gene Inhibited

C09B9.6 (msp-55)

Description of "C09B9.6"

msp-55 encodes a member of the major sperm protein family.

Evidence for Inhibition

Sliding Window	Raw score: 75 Relative score: 0.185 (Best raw score= for Gene ) Specificity index: 0.022
Wormbase (BLAST)	RNAi secondary

External "C09B9.6" Links

Gene Inhibited

F36H12.7 (msp-19)

Description of "F36H12.7"

msp-19 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-19 has a homolog in C. briggsae as predicted by the Wobble Aware Bulk Aligner (WABA); the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 142 Relative score: 0.35 (Best raw score= for Gene ) Specificity index: 0.042
Wormbase (BLAST)	RNAi secondary

External "F36H12.7" Links

Gene Inhibited

Y59E9AR.1

Description of "Y59E9AR.1"

Associated GO Term : structural molecule activity

Evidence for Inhibition

Sliding Window	Raw score: 98 Relative score: 0.241 (Best raw score= for Gene ) Specificity index: 0.029
Wormbase (BLAST)	RNAi secondary

External "Y59E9AR.1" Links

Gene Inhibited

R13H9.2 (msp-57)

Description of "R13H9.2"

msp-57 encodes a member of the major sperm protein family.

Evidence for Inhibition

Sliding Window	Raw score: 96 Relative score: 0.236 (Best raw score= for Gene ) Specificity index: 0.028
Wormbase (BLAST)	RNAi secondary

External "R13H9.2" Links

Gene Inhibited

K08F4.8 (msp-38)

Description of "K08F4.8"

msp-38 encodes a member of the major sperm protein family; msp-38 has a C. briggsae homolog as predicted by the Wobble Bulk Aware Bulk Aligner (WABA).

Evidence for Inhibition

Sliding Window	Raw score: 66 Specificity index: 0.019
Wormbase (BLAST)	RNAi secondary

External "K08F4.8" Links

Gene Inhibited

ZK546.3

Description of "ZK546.3"

Associated GO Term : structural molecule activity

Evidence for Inhibition

Sliding Window	Raw score: 194 Relative score: 0.478 (Best raw score= for Gene ) Specificity index: 0.057
Wormbase (BLAST)	RNAi primary

External "ZK546.3" Links

Gene Inhibited

ZK354.5 (msp-51)

Description of "ZK354.5"

msp-51 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-51 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 90 Relative score: 0.222 (Best raw score= for Gene ) Specificity index: 0.026
Wormbase (BLAST)	RNAi secondary

External "ZK354.5" Links

Gene Inhibited

ZK354.10 (msp-58)

Description of "ZK354.10"

msp-58 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 110 Relative score: 0.271 (Best raw score= for Gene ) Specificity index: 0.032
Wormbase (BLAST)	RNAi secondary

External "ZK354.10" Links

Gene Inhibited

T13F2.10 (msp-79)

Description of "T13F2.10"

msp-79 encodes a member of the major sperm protein family.

Evidence for Inhibition

Sliding Window	Raw score: 66 Specificity index: 0.019
Wormbase (BLAST)	RNAi secondary

External "T13F2.10" Links

Gene Inhibited

F32B6.6 (msp-77)

Description of "F32B6.6"

msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 66 Relative score: 0.163 (Best raw score= for Gene ) Specificity index: 0.019
Wormbase (BLAST)	RNAi secondary

External "F32B6.6" Links

Gene Inhibited

F58A6.8 (msp-45)

Description of "F58A6.8"

msp-45 encodes a member of the major sperm protein family.

Evidence for Inhibition

Sliding Window	Raw score: 95 Specificity index: 0.028
Wormbase (BLAST)	RNAi secondary

External "F58A6.8" Links

Gene Inhibited

C34F11.4 (msp-50)

Description of "C34F11.4"

msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 76 Relative score: 0.187 (Best raw score= for Gene ) Specificity index: 0.022
Wormbase (BLAST)	RNAi secondary

External "C34F11.4" Links

Gene Inhibited

C33F10.9 (msp-40)

Description of "C33F10.9"

msp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 79 Relative score: 0.195 (Best raw score= for Gene ) Specificity index: 0.023
Wormbase (BLAST)	RNAi secondary

External "C33F10.9" Links

Gene Inhibited

R13H9.4 (msp-53)

Description of "R13H9.4"

msp-53 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-53 has a C. briggsae homolog as identified by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 123 Relative score: 0.303 (Best raw score= for Gene ) Specificity index: 0.036
Wormbase (BLAST)	RNAi secondary

External "R13H9.4" Links

Gene Inhibited

ZK354.4 (msp-113)

Description of "ZK354.4"

msp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 89 Relative score: 0.219 (Best raw score= for Gene ) Specificity index: 0.026
Wormbase (BLAST)	RNAi secondary

External "ZK354.4" Links

Gene Inhibited

ZK354.11 (msp-59)

Description of "ZK354.11"

msp-59 encodes a member of the major sperm protein family.

Evidence for Inhibition

Sliding Window	Raw score: 95 Relative score: 0.234 (Best raw score= for Gene ) Specificity index: 0.028
Wormbase (BLAST)	RNAi secondary

External "ZK354.11" Links

Gene Inhibited

T13F2.11 (msp-78)

Description of "T13F2.11"

msp-78 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 59
Wormbase (BLAST)	RNAi secondary

External "T13F2.11" Links

Gene Inhibited

C34F11.6 (msp-49)

Description of "C34F11.6"

msp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 88 Relative score: 0.217 (Best raw score= for Gene ) Specificity index: 0.026
Wormbase (BLAST)	RNAi secondary

External "C34F11.6" Links

Gene Inhibited

K05F1.2 (msp-142)

Description of "K05F1.2"

msp-142 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 86 Relative score: 0.212 (Best raw score= for Gene ) Specificity index: 0.025
Wormbase (BLAST)	RNAi secondary

External "K05F1.2" Links

Gene Inhibited

F26G1.7 (msp-3)

Description of "F26G1.7"

msp-3 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-3 is similar in nucleotide sequence to the msp genes from the nematode Onchocerca volvulus; the msp gene family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP proteins assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 101 Relative score: 0.249 (Best raw score= for Gene ) Specificity index: 0.03
Wormbase (BLAST)	RNAi secondary

External "F26G1.7" Links

Gene Inhibited

ZK354.1 (msp-65)

Description of "ZK354.1"

msp-65 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 92 Relative score: 0.227 (Best raw score= for Gene ) Specificity index: 0.027
Wormbase (BLAST)	RNAi secondary

External "ZK354.1" Links

Gene Inhibited

ZK546.6 (msp-152)

Description of "ZK546.6"

msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 236 Relative score: 0.581 (Best raw score= for Gene ) Specificity index: 0.069
Wormbase (BLAST)	RNAi primary

External "ZK546.6" Links

Gene Inhibited

F58A6.9

Description of "F58A6.9"

Associated GO Term : structural molecule activity

Evidence for Inhibition

Sliding Window	Raw score: 81 Relative score: 0.2 (Best raw score= for Gene ) Specificity index: 0.024
Wormbase (BLAST)	RNAi secondary

External "F58A6.9" Links

Gene Inhibited

F26G1.8 (msp-42)

Description of "F26G1.8"

msp-42 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 77 Relative score: 0.19 (Best raw score= for Gene ) Specificity index: 0.023
Wormbase (BLAST)	RNAi secondary

External "F26G1.8" Links

Gene Inhibited

K07F5.3 (msp-56)

Description of "K07F5.3"

msp-56 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 64 Relative score: 0.158 (Best raw score= for Gene ) Specificity index: 0.019
Wormbase (BLAST)	RNAi secondary

External "K07F5.3" Links

Gene Inhibited

F36H12.6 (msp-52)

Description of "F36H12.6"

msp-52 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition

Sliding Window	Raw score: 104 Relative score: 0.256 (Best raw score= for Gene ) Specificity index: 0.03
Wormbase (BLAST)	RNAi primary

External "F36H12.6" Links

Gene Inhibited

R05F9.13 (msp-31)

Description of "R05F9.13"

msp-31 encodes a member of the major sperm protein family; msp-31 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); expression is enriched in sperm.

Evidence for Inhibition

Sliding Window	Raw score: 169 Relative score: 0.416 (Best raw score= for Gene ) Specificity index: 0.049
Wormbase (BLAST)	RNAi primary

External "R05F9.13" Links

Gene Inhibited

F59A6.8 (msp-71)

Description of "F59A6.8"

msp-71 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.

Evidence for Inhibition