Link to Y47D3B.6Link to Y47D3B.7RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
RNAi Experiment: [cgc5707]:lpd-1 Ace View of [cgc5707]:lpd-1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y47D3B.7 (sbp-1)
Description of "Y47D3B.7"  sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood.
KOG Annotation  Predicted DNA-binding protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:11436788..11437719)
Transcript overlap: 779 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 698
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y47D3B.7" Links  Wormbase NCBI
[cgc5707]:lpd-1 Phenotypes Help with Phenotypes
Phenotype  Lpd
Unclassified expression of several lipogenic enzymes, including acetyl coenzyme A carboxylase, ATP-citrate lyase, fatty acid synthase, glycerol 3-phosphate acyltransferase, and malic enzyme is downregulated
[cgc5707]:lpd-1 Experiment Details Ace View
RNAi Reagent & Type  sjj_Y47D3B.7 (PCR_reagent)
Reference  McKay RM et al. (2003) Developmental Cell "C. elegans: a model for exploring the genetics of fat storage."
Delivery Method  Injection
Date  2003-1-01
Gene Plot of Y47D3B.7 Browse using GBrowse
Gene Graph