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RNAi Experiment: [cgc5728]:elo-2a Ace View of [cgc5728]:elo-2a
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F11E6.5 (elo-2)
Description of "F11E6.5"  The elo-2 gene encodes a palmitic acid elongase, homologous to polyunsaturated fatty acid (PUFA) elongases such as ELO-1, that is required for normally rapid growth, normally large body size, fertility, and for the quantitative regulation of the ultradian defecation rhythm; the joint action of ELO-2 with ELO-1 is strongly required for 20-carbon PUFA production and for general viability; elo-2 is most strongly expressed in intestinal cells, as well as other tissues such as the ventral nerve cord, pharyngeal muscles, uterus, and tail.
KOG Annotation  Long chain fatty acid elongase
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 641
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F11E6.5" Links  Wormbase NCBI
[cgc5728]:elo-2a Phenotypes Help with Phenotypes
Adult  Sck in elo-1(gk48) background
Phenotype  Reproductive defect in elo-1(gk48) background brood size of P0 is reduced to 30-40 worms
Unclassified in elo-1(gk48) background 20-carbon polyunsaturated fatty acid fractions are nearly eliminated
[cgc5728]:elo-2a Experiment Details Ace View
RNAi Reagent & Type  [cgc5728]:elo-2a (PCR_reagent)
Reference  Kniazeva M et al. (2003) Genetics "Suppression of the ELO-2 FA elongation activity results in alterations of the ...."
Delivery Method  Bacterial_feeding
Date  2002-10-23
Gene Plot of F11E6.5 Browse using GBrowse
Gene Graph