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RNAi Experiment: [cgc6004]:zif-1 Ace View of [cgc6004]:zif-1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F59B2.6 (zif-1)
Description of "F59B2.6"  zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
Evidence for Inhibition 
Sliding Window Raw score: 1323
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F59B2.6" Links  Wormbase NCBI
[cgc6004]:zif-1 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
[cgc6004]:zif-1 Experiment Details Ace View
RNAi Reagent & Type  [cgc6004]:zif-1 (cDNA_reagent)
Remark  supplemental material at ftp.wormbase.org/pub/wormbase/datasets/derenzo_2003
Reference  DeRenzo C et al. (2003) Nature "Exclusion of germ plasm proteins from somatic lineages by cullin-dependent ...."
Delivery Method  Bacterial_feeding
Date  2003-8-07
Gene Plot of F59B2.6 Browse using GBrowse
Gene Graph