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RNAi Experiment: Cenix:10-e3 Ace View of Cenix:10-e3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F32H2.3 (spd-2)
Description of "F32H2.3"  spd-2 encodes a protein with three predicted coiled-coil domains; SPD-2 activity is essential for centrosome maturation and duplication, and hence for proper mitotic spindle assembly; in regulating the early steps of centrosome maturation, SPD-2 acts together with the coiled-coil protein SPD-5, the Aurora-A kinase AIR-1, and the cytoplasmic dynein DHC-1; in regulating centrosome duplication, SPD-2 likely acts together with the ZYG-1 kinase; in both processes, SPD-2 may function to recruit centrosomal components such as ZYG-9 and microtubule-nucleating gamma-tubulin complexes to the developing centrosome; within centrosomes, SPD-2 localizes to both centrioles and the pericentriolar material; efficient centrosomal localization depends upon AIR-1 and DHC-1, while localization specifically to the pericentriolar material depends upon SPD-5.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:8968087..8968637)
Transcript overlap: 551 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 530
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F32H2.3" Links  Wormbase NCBI Phenobank 1
Cenix:10-e3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Spindle Assembly abnormal
External Movies 
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Cenix:10-e3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:10-e3 (PCR_reagent)
Remark  early embryonic: Spindle Assembly
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F32H2.3 Browse using GBrowse
Gene Graph