Ace View of Cenix:125-h7 | |||
Gene Inhibited | R05D11.3 (ran-4) | ||
Description of "R05D11.3" | ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo. | ||
KOG Annotation  | Nuclear transport factor 2 |
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Evidence for Inhibition | |||
External "R05D11.3" Links | 1 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | Pronuclear/Nuclear Appearance abnormal |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:125-h7 (PCR_reagent) | ||
Remark | early embryonic: Pronuclear/Nuclear Appearance | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of R05D11.3 | |||