| RNAi Experiment: Cenix:125-h7 |
Ace View of Cenix:125-h7
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| Genes Inhibited |
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| Gene Inhibited |
R05D11.3 (ran-4) |
| Description of "R05D11.3" |
ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo. |
| KOG Annotation |
Nuclear transport factor 2
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (I:8591234..8591731)
Transcript overlap: 369 nt |
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| Sliding Window |
Raw score: 285
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "R05D11.3" Links |
   1 |
| Cenix:125-h7 Phenotypes |
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| Embryonic |
Emb Penetrance None reported |
| Phenotype |
Pronuclear/Nuclear Appearance abnormal
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External Movies
(Please note that RNAiDB is not
hosting these data.) |
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| Cenix:125-h7 Experiment Details |
Ace View |
| Laboratory |
TH |
| RNAi Reagent & Type |
Cenix:125-h7 (PCR_reagent) |
| Remark |
early embryonic: Pronuclear/Nuclear Appearance |
| Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
| Delivery Method |
Injection |
| Date |
2005-3-24 |
| Gene Plot of R05D11.3 |
Browse using GBrowse
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