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RNAi Experiment: Cenix:125-h7 Ace View of Cenix:125-h7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R05D11.3 (ran-4)
Description of "R05D11.3"  ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo.
KOG Annotation  Nuclear transport factor 2
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:8591234..8591731)
Transcript overlap: 369 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 285
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R05D11.3" Links  Wormbase NCBI Phenobank 1
Cenix:125-h7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Pronuclear/Nuclear Appearance abnormal
External Movies 
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Cenix:125-h7 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:125-h7 (PCR_reagent)
Remark  early embryonic: Pronuclear/Nuclear Appearance
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of R05D11.3 Browse using GBrowse
Gene Graph