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RNAi Experiment: Cenix:13-a9 Ace View of Cenix:13-a9
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C32F10.2 (lin-35)
Description of "C32F10.2"  lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
KOG Annotation  Rb (Retinoblastoma tumor suppressor)-related protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:5812414..5812918)
Transcript overlap: 505 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 484
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C32F10.2" Links  Wormbase NCBI Phenobank 1
Cenix:13-a9 Phenotypes Help with Phenotypes
Phenotype  WT
External Movies 
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Cenix:13-a9 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:13-a9 (PCR_reagent)
Remark  early embryonic: Overall wildtype.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C32F10.2 Browse using GBrowse
Gene Graph