Ace View of Cenix:13-h12 | |||
Gene Inhibited | C08B6.9 (aos-1) | ||
Description of "C08B6.9" | aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | ||
KOG Annotation  | SMT3/SUMO-activating complex, AOS1/RAD31 component |
||
Evidence for Inhibition | |||
External "C08B6.9" Links | 1 | ||
Embryonic | Emb Penetrance None reported | ||
Phenotype | WT_postembryonic_morphology |
||
External Movies (Please note that RNAiDB is not hosting these data.) |
|||
Laboratory | TH | ||
RNAi Reagent & Type | Cenix:13-h12 (PCR_reagent) | ||
Remark | early embryonic: Overall wildtype. | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of C08B6.9 | |||