Ace View of Cenix:137-e7 | |||
Gene Inhibited | C12C8.3 (lin-41) | ||
Description of "C12C8.3" | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | ||
KOG Annotation  | Predicted E3 ubiquitin ligase |
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Evidence for Inhibition | |||
External "C12C8.3" Links | 1 2 | ||
Adult | Sterile F0/Fertility Problems Sterility/Impaired Fertility in F0 |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:137-e7 (PCR_reagent) | ||
Remark | early embryonic: Sterility/Impaired Fertility in F0 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of C12C8.3 | |||