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RNAi Experiment: Cenix:138-d8 Ace View of Cenix:138-d8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F14B8.1 (nhx-4)
Description of "F14B8.1"  nhx-4 encodes two isoforms of a sodium/proton exchanger expressed in the plasma membrane of nearly all cells and cell types; in polarized epithelial cells, NHX-4::GFP appears specifically located in the basolateral membrane, like human SLC9A1 ('NHE1'; OMIM:107310); nhx-4 has no reported mutant or RNAi phenotype, but, given its ubiquitous expression, may represent a housekeeping exchanger generally required for cellular viability; transgenic NHX-4A, when expressed in cell culture, mediates Na[+]-dependent pH recovery after intracellular acidification, independently of extracellular Cl[-].
Evidence for Inhibition 
ePCR Status: Unique_ePCR (X:6919215..6920413)
Transcript overlap: 687 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 582
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F14B8.1" Links  Wormbase NCBI Phenobank 1 2
Cenix:138-d8 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Complex Phenotype
External Movies 
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Cenix:138-d8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:138-d8 (PCR_reagent)
Remark  early embryonic: Complex Phenotype
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of F14B8.1 Browse using GBrowse
Gene Graph