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RNAi Experiment: Cenix:141-a11 Ace View of Cenix:141-a11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W07B3.2 (gei-4)
Description of "W07B3.2"  gei-4 encodes a protein with a coiled-coil domain (predicted to mediate protein-protein interactions), an internal repeat of 69 residues (covering residues 134-202, 203-265, and 266-328 of W07B3.2a), and a glutamine/asparagine-rich domain; GEI-4 is paralogous to Y50D7A.8 and Y59C2A.3, physically interacts with GEX-2, and is required for embryonic viability, fertility, and vulval morphogenesis; GEI-4 is claimed to have weak homology to trichohyalin, a mammalian intermediate filament interacting protein; the similarity of the mutant phenotypes of gei-4, gex-2 and gex-3 and their interaction sugggest that the GEX-2/GEX-3/GEI-4 protein complex is essential for the regulation of intermediate filaments during rearrangement of the cytoskeleton that occurs in embryogenesis; GFI-2, an ankyrin-repeat protein associates with GEI-4 and exhibits a similar mutant phenotype, suggesting that gfi-2 is also involved in intermediate filament dynamics.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:345413..346487)
Transcript overlap: 680 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 638
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W07B3.2" Links  Wormbase NCBI Phenobank 1 2 3 4
Cenix:141-a11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  WT_postembryonic_morphology
External Movies 
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Cenix:141-a11 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:141-a11 (PCR_reagent)
Remark  100% embryonic lethality .
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of W07B3.2 Browse using GBrowse
Gene Graph