RNAi Experiment: Cenix:141-b8 |
Ace View of Cenix:141-b8
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Genes Inhibited |
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Gene Inhibited |
T24D1.1 (sqv-5) |
Description of "T24D1.1" |
sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:9949114..9950310)
Transcript overlap: 757 nt |
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Sliding Window |
Raw score: 716
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "T24D1.1" Links |
1 |
Cenix:141-b8 Phenotypes |
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Phenotype |
WT
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Cenix:141-b8 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:141-b8 (PCR_reagent) |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of T24D1.1 |
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