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RNAi Experiment: Cenix:141-d10 Ace View of Cenix:141-d10
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W05E10.3 (ceh-32)
Description of "W05E10.3"  ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro.
KOG Annotation  Transcription factor SIX and related HOX domain proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (V:11704663..11705745)
Transcript overlap: 783 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 762
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W05E10.3" Links  Wormbase NCBI Phenobank 1
Cenix:141-d10 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:141-d10 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:141-d10 (PCR_reagent)
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of W05E10.3 Browse using GBrowse
Gene Graph