Ace View of Cenix:141-f9 | ||||||
Gene Inhibited | W02B9.1 (hmr-1) | |||||
Description of "W02B9.1" | hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. | |||||
KOG Annotation  | Cadherin repeats |
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Evidence for Inhibition | ||||||
External "W02B9.1" Links | 1 2 | |||||
Gene Inhibited | Y52B11A.11 | |||||
Evidence for Inhibition |
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External "Y52B11A.11" Links | 1 2 | |||||
Embryonic | Emb Penetrance None reported | |||||
Phenotype | WT_postembryonic_morphology |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | |||||
RNAi Reagent & Type | Cenix:141-f9 (PCR_reagent) | |||||
Remark | early embryonic: No significant defects seen. | |||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | |||||
Delivery Method | Injection | |||||
Date | 2005-3-24 | |||||
Gene Plot of Y52B11A.11 | ||||||
Gene Plot of W02B9.1 | ||||||