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RNAi Experiment: Cenix:142-b3 Ace View of Cenix:142-b3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y43F4B.6 (klp-19)
Description of "Y43F4B.6"  klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone.
KOG Annotation  Kinesin-like protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:13302707..13303901)
Transcript overlap: 755 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 692
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y43F4B.6" Links  Wormbase NCBI Phenobank 1
Cenix:142-b3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Chromosome Segregation (karyomeres) abnormal
External Movies 
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Cenix:142-b3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:142-b3 (PCR_reagent)
Remark  early embryonic: Chromosome Segregation (karyomeres)
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of Y43F4B.6 Browse using GBrowse
Gene Graph