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RNAi Experiment: Cenix:145-c8 Ace View of Cenix:145-c8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0334.11 (ooc-3)
Description of "B0334.11"  ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:11494133..11495275)
Transcript overlap: 883 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 791
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0334.11" Links  Wormbase NCBI Phenobank 1 2
Cenix:145-c8 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Complex Phenotype
External Movies 
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Cenix:145-c8 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:145-c8 (PCR_reagent)
Remark  early embryonic: Complex Phenotype
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of B0334.11 Browse using GBrowse
Gene Graph