RNAi Experiment: Cenix:149-d4 |
Ace View of Cenix:149-d4
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Genes Inhibited |
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Gene Inhibited |
R06C7.7 (lin-61) |
Description of "R06C7.7" |
lin-61 encodes a protein that contains mbt repeats and has similarity to the Drosophila Polycomb group protein Sex Comb on Midleg and human protein H-l-(3)mbl-like; by homology, LIN-61 is predicted to function as part of a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and forward mutations indicates that LIN-61 is required for: 1) genome stability in the soma and germline, and 2) postembryonic developmental processes such as vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene. |
KOG Annotation  |
Polycomb group protein SCM/L(3)MBT (tumor-supressor in Drosophila and humans)
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:7248902..7250101)
Transcript overlap: 1059 nt |
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Sliding Window |
Raw score: 996
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R06C7.7" Links |
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Cenix:149-d4 Phenotypes |
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Phenotype |
WT
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Cenix:149-d4 Experiment Details |
Ace View |
Laboratory |
TH |
RNAi Reagent & Type |
Cenix:149-d4 (PCR_reagent) |
Remark |
Wildtype results for all three tests. |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Delivery Method |
Injection |
Date |
2005-3-24 |
Gene Plot of R06C7.7 |
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