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RNAi Experiment: Cenix:151-a7 Ace View of Cenix:151-a7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  Y37E11C.1 (unc-33)
Description of "Y37E11C.1"  unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:3523380..3524864)
Transcript overlap: 872 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 830
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "Y37E11C.1" Links  Wormbase NCBI Phenobank 1 2 3
Cenix:151-a7 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:151-a7 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:151-a7 (PCR_reagent)
Remark  3/3 wild type
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of Y37E11C.1 Browse using GBrowse
Gene Graph