Ace View of Cenix:16-h12 | |||||
Gene Inhibited | K04G2.9 | ||||
Description of "K04G2.9" | Associated GO Term : membrane | ||||
KOG Annotation  | Members of chemokine-like factor super family and related proteins |
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Evidence for Inhibition | |||||
External "K04G2.9" Links | 1 | ||||
Gene Inhibited | K04G2.8 (apr-1) | ||||
Description of "K04G2.8" | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. | ||||
KOG Annotation  | Beta-catenin-binding protein APC, contains ARM repeats |
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Evidence for Inhibition |
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External "K04G2.8" Links | 1 | ||||
Phenotype | WT |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||||
RNAi Reagent & Type | Cenix:16-h12 (PCR_reagent) | ||||
Remark | early embryonic: Clear cut result. | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
Delivery Method | Injection | ||||
Date | 2005-3-24 | ||||
Gene Plot of K04G2.9 | |||||
Gene Plot of K04G2.8 | |||||