Ace View of Cenix:18-h3 | |||
Gene Inhibited | F07A5.7 (unc-15) | ||
Description of "F07A5.7" | The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. | ||
KOG Annotation  | Myosin class II heavy chain |
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Evidence for Inhibition | |||
External "F07A5.7" Links | 1 | ||
Phenotype | Larval Lethal-Late (L3/L4) |
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External Movies (Please note that RNAiDB is not hosting these data.) |
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Laboratory | TH | ||
RNAi Reagent & Type | Cenix:18-h3 (PCR_reagent) | ||
Remark | early embryonic: Two independent experiments, one of which showed a non-reproducible polar body extrusion defect. | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of F07A5.7 | |||