Ace View of Cenix:186-d3 | |||
Gene Inhibited | K08E7.3 (let-99) | ||
Description of "K08E7.3" | let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position). | ||
Evidence for Inhibition | |||
External "K08E7.3" Links | ![]() ![]() ![]() |
||
Embryonic | Emb Penetrance None reported | ||
Phenotype | Pnm |
||
External Movies (Please note that RNAiDB is not hosting these data.) |
![]() |
||
Laboratory | TH | ||
RNAi Reagent & Type | Cenix:186-d3 (PCR_reagent) | ||
Remark | early embryonic: Pronuclear Migration | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Delivery Method | Injection | ||
Date | 2005-3-24 | ||
Gene Plot of K08E7.3 | |||
![]() |