Link to R06F6.1.1Link to R06F6.1.2Link to R06F6.11RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: Cenix:200-b11 Ace View of Cenix:200-b11
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R06F6.1 (cdl-1)
Description of "R06F6.1"  cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs.
KOG Annotation  Histone mRNA stem-loop binding protein
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:10785583..10786345)
Transcript overlap: 649 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 586
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R06F6.1" Links  Wormbase NCBI Phenobank 1
Cenix:200-b11 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance None reported
Phenotype  Sister Chromatid Separation abnormal (Cross-eyed)
External Movies 
(Please note that RNAiDB is not
hosting these data.)
/static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif
/static/images/movie.gif
Help
Cenix:200-b11 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:200-b11 (PCR_reagent)
Remark  early embryonic: Sister Chromatid Separation (Cross-eyed)
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of R06F6.1 Browse using GBrowse
Gene Graph