Link to C47D12.7Link to C47D12.8Link to VF13D12L.1.1Link to VF13D12L.1.2RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: Cenix:200-h3 Ace View of Cenix:200-h3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C47D12.8
Description of "C47D12.8"  C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
KOG Annotation  Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:11696272..11696979)
Transcript overlap: 653 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 611
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C47D12.8" Links  Wormbase NCBI Phenobank 1
Cenix:200-h3 Phenotypes Help with Phenotypes
Phenotype  WT
Cenix:200-h3 Experiment Details Ace View
Laboratory  TH
RNAi Reagent & Type  Cenix:200-h3 (PCR_reagent)
Remark  3/3 tests are wildtype.
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Delivery Method  Injection
Date  2005-3-24
Gene Plot of C47D12.8 Browse using GBrowse
Gene Graph